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health:cancer
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health:cancer [2019/08/12 15:58] saira [Head and Neck Cancer] |
health:cancer [2019/10/26 20:54] (current) marcos [Mutational Theory of Cancer] |
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| These very few mutated cells may in some way be able to out-compete neighboring cells. While these cells could have advantage over neighboring cells in terms of competitive survival, they may not necessarily be the most effective towards the overall health of the organism. This is an aspect of the aging process. In the case of cancer, the mutated cell proliferation will likely cause an organism's death. | These very few mutated cells may in some way be able to out-compete neighboring cells. While these cells could have advantage over neighboring cells in terms of competitive survival, they may not necessarily be the most effective towards the overall health of the organism. This is an aspect of the aging process. In the case of cancer, the mutated cell proliferation will likely cause an organism's death. | ||
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| + | Mutated cells can happen in different stages of life, and results in [[https://dx.doi.org/10.1016%2Fj.gde.2016.12.002 |clonal mosaicism]], including where different regions of the body have differing genomes. | ||
| The imperfections in the machinery for DNA maintenance and DNA replication, could be more exact and fault tolerant. However, a certain level of mutation is beneficial for the survival of a species in a changing environment. Cancer and aging are products of the evolutionary process. | The imperfections in the machinery for DNA maintenance and DNA replication, could be more exact and fault tolerant. However, a certain level of mutation is beneficial for the survival of a species in a changing environment. Cancer and aging are products of the evolutionary process. | ||
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| In head and neck cancer, it’s been hypothesized that carbohydrate restriction and ketosis can be supportive treatments by protecting normal tissue while sensitizing tumor tissue to radiation and chemotherapy while simultaneously supporting body and muscle mass maintenance.32 There is currently an active clinical trial looking at a low carbohydrate diet in head and neck cancer patients. | In head and neck cancer, it’s been hypothesized that carbohydrate restriction and ketosis can be supportive treatments by protecting normal tissue while sensitizing tumor tissue to radiation and chemotherapy while simultaneously supporting body and muscle mass maintenance.32 There is currently an active clinical trial looking at a low carbohydrate diet in head and neck cancer patients. | ||
| - | === Prevention === | ||
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| - | Of all the food items explored in a 1991 Italian study, such as, milk, meat, cheese, carrots, green vegetables and fruit, fruit had the strongest statistical indication for being a preventative. The top third of subjects reporting the highest fruit consumption had a risk ratio of 0.3, or less than one third as likely to have oral and pharyngeal cancer as the population. ((Carlo La Vecchia et al. 1991. Dietary Indicators of Oral and Pharyngeal Cancer. https://doi.org/10.1093/ije/20.1.39)) <- Notice I'm using CSE-ish format! | ||
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| - | Another study took blood samples from 25,802 subjects in 1974, and stored them in the freezer until 1991. Of the 25,802 subjects, 28 cases had been diagnosed with oral and pharyngeal cancer. The blood of the 28 cases was compared with controls from similar subjects, and was found to be lacking in micronutrients, particularly carotenoids and alpha-tocopherol.While interestingly it was also indicated that high level y-tocopherol can change whole scenario and reverse the situation. Selenium which is cancer protective but their high level can be cancer causing((Birt et al., 1986.update on the effects of vitamins A, C, and E and selenium on carcinogenesis..https://www.ncbi.nlm.nih.gov/pubmed/3540970 )). while considering all micro nutrient protective effect of b-carotenoids was more consistent and significant. It was was found that diet containing higher concentration of b-carotenoids is more preferable to use to avoid oral cancer risk. | ||
| - | As had been concluded in previous studies, smoking reduces blood micronutrients specially a-tocopherols and b-carotenoids and increases the risk of oral cancer. ((Zheng et al. 1993. Serum Micronutrients and the Subsequent Risk of Oral and Pharyngeal Cancer. https://www.ncbi.nlm.nih.gov/pubmed/8428360)) | ||
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| - | Vitamin A is commonly used as protective agent against lung cancer and halve tested in many clinical trials.Basically Vitamin A is common term for many compouNds of Vitamin A. Retinoids /Vitamin A has protective effect in lung cancer patients. Trans retinoic acid reduces the production of oral cancerous lesions and have very dramatic anti tumor effect. Nuclear signalling receptors of retinoids are the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs).Retinoic acid receptors are more efficient in depressions of malignant tumor progression than retinoid X receptors for retinois. In smokers there is low level of Vitamin A being observed. Smoking induce squamous metaplasia which leads to squamous cell lung carcinoma ((Poulain et al., 2009.Vitamin A/retinoids signalling in the human lung.https://www.ncbi.nlm.nih.gov/pubmed/19346027)). | ||
| ==== Endometrial Cancer ==== | ==== Endometrial Cancer ==== | ||
health/cancer.1565625526.txt.gz · Last modified: 2019/08/12 15:58 by saira
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