Differences

This shows you the differences between two versions of the page.

--- health:drug-allergy-testing [2018/04/19 07:03]
marcos [Pharmaceuticals for Depression]
+++ health:drug-allergy-testing [2020/04/27 01:48] (current)
marcos
@@ Line 1: / Line 1: @@
+====== Drug Allergy Testing ======
 Pharmaceutical companies can make no profit from herbs which humans have historically consumed.  Instead, they create new molecules.  They have a hard time creating molecules that affect only the system they want to affect, therefore there are inevitably side effects.
-I hypothesize that all too many of these side effects are allergic in nature.  You are taking a fabricated molecule that has never been seen before by human cells.  In this case, you are likely messing with your immune system, creating new allergies that wouldn't have otherwise existed, and are detrimental to the long term health of your immune system.
+Quora: [[https://www.quora.com/How-much-does-medical-science-know-about-human-body-and-its-function
+ |How much does medical science know about the human body and its functions]]
-It would be wise to perform an allergy test for any drug you might take, just like you would to find out if you have a food allergy.\\
+{{:health:chainsawsuit.png|}}
+Nature, evolution, has done a better job at choosing which molecules are beneficial.  All life is based on DNA, and molecules that are beneficial in one organism are likely to be beneficial for other organisms, which is why they consume each other for nutrients (not just for energy).
+The odds that a pharmaceutical will have long term deleterious consequences are higher, if only because the molecule in question was not selected by nature for DNA based life forms.  An allergic reaction can always be dangerous, but in the case of a pharmaceutical, the immune system can be challenged in a way in which evolution has no bearing.
+" Our lack of understanding of the global interactions between pharmaceuticals and the immune system confounds drug development, conceals potentially serious side effects of marketed compounds " [[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706827 |source]]
+For any of the systems in the human body, reliable studies on long term effect from pharmaceuticals are lacking.  Science is just beginning to understand the epigenome.
+I believe the age of pharma will be an embarrassment to humanity, much like the former practices of [[https://en.wikipedia.org/wiki/Bloodletting |bloodletting]] and [[https://en.wikipedia.org/wiki/Lobotomy |labotomies]].
+//"behavioral ethics research suggests that an especially large proportion of the population (in some studies more than 50%) may behave unethically, because their ability to objectively interpret the ethicality of their own behavior is highly limited."//  [[https://hbr.org/2019/03/companies-need-to-pay-more-attention-to-everyday-unethical-behavior |source]]
+For any pharmaceutical a doctor prescribes, it would be wise to perform an allergy test, just like you would to find out if you have a food allergy.\\
 https://www.mayoclinic.org/diseases-conditions/drug-allergy/diagnosis-treatment/drc-20371839\\
 https://www.sciencedirect.com/science/article/pii/S0300483X04007267\\
-http://onlinelibrary.wiley.com/doi/10.1046/j.0105-4538.2001.00001.x-i8/full?wol1URL=/doi/10.1046/j.0105-4538.2001.00001.x-i8/full&regionCode=US-NY&identityKey=8d26dfc5-1c86-4200-8dc3-866ae0c45a33
+http://onlinelibrary.wiley.com/doi/10.1046/j.0105-4538.2001.00001.x-i8/full?wol1URL=/doi/10.1046/j.0105-4538.2001.00001.x-i8/full&regionCode=US-NY&identityKey=8d26dfc5-1c86-4200-8dc3-866ae0c45a33\\
 http://onlinelibrary.wiley.com/doi/10.1111/all.12142/full\\
 http://onlinelibrary.wiley.com/doi/10.1111/all.12350/full
-==== Pharmaceuticals for Depression ====
+Pharmaceutical drugs usually have a lot of unwanted side effects.  So when your doctor suggests you take a certain drug, just tell them you'd like to first get an allergy test on that drug.  There will likely be resistance and excuses towards not doing so, like trying to tell you that side effects are not allergies.  While it is true that there can be effects not related to the immune system, toxicity can lead to an unnatural immune response.
-The most common drugs used for depression are SSRI's (selective serotonin reuptake inhibitors).  This is an alternative to just providing more serotonin.  If additional serotonin is provided via supplementation of 5-htp, the drive for neurotransmitter homeostasis will quickly consume the excess serotonin.  Thus, a person would have to take 5-htp frequently, and the levels of serotonin would be somewhat of a rollercoaster.  One solution is to have a time-release dosage: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946063.  5-htp is not a harmful chemical, but a naturally occurring metabolite.  It is a metabolite of tryptophan.  Tryptophan is an amino acid, but although naturally occuring in food, it's metabolism creates toxic by-products in addition to 5-htp, so taking 5-htp is healthier.
-[[https://examine.com/supplements/5-htp/#summary6 | SSRI's have a lot more side effects than 5-htp]].  So when your psychiatrist suggests you take a certain drug, just tell them you'd like to first get an allergy test on that drug.  There will likely be resistance and excuses towards not doing so, like trying to tell you that side effects are not allergies.  In any case, you shouldn't be allergic to any drug you take, so what's the harm of a small test?  Never mind that if you chew the pill in your mouth, it leaves a burn mark in your gums.  Maybe the digestion process takes care of that, but maybe it doesn't.  They test for food allergies by placing the food on your skin, so why shouldn't it be the same for a drug?  If I learn more about this, I will add the info here.
+You shouldn't be allergic to any drug you take, so what's the harm of a small test?  Never mind that if you chew the pill in your mouth and let it sit for a minute, it leaves a burn on your gums.  Your gums are made of cells just like the rest of your body.  They test for food allergies by placing the food on your skin, so why shouldn't it be the same for a drug?
-https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686152\\
+Maybe digestion chemically alters the molecule, but all too often, pharmaceuticals wreck havoc on the digestive system:\\
-" However, multiple negative effects of SSRI treatment during pregnancy have recently been identified, with the limitation that it is often difficult to control for confounding effects of maternal psychopathology. Ultrasonic investigation of human fetuses provides evidence that SSRIs taken during pregnancy alter the brain physiology starting as early as the beginning of second trimester (Mulder et al., 2011). Combined recordings of general motor activity, rapid eye movements, and fetal heart rate variability indicate that fetuses exposed to SSRIs during gestation have abnormal increases in motor movements during phases of non-REM sleep compared to fetuses from drug-free mothers with comparable levels of anxiety and depressive symptoms. Furthermore blood flow recordings at 36 weeks gestation in the middle cerebral artery were significantly decreased in fetuses exposed to SSRIs during gestation (Rurak et al., 2011). At birth, babies prenatally exposed to SSRIs display a wide range of neurobehavioral alterations, including lower APGAR scores, increased irritability, and blunted pain reactivity (Casper et al., 2003; Oberlander et al., 2005), as well as reduced fetal head growth (El Marroun et al., 2012). More recently prenatal antidepressants were shown to shift developmental milestones on infant speech perception tasks in utero and at 6 and 10 month of age (Weikum et al., 2012), suggesting a role for 5-HT in modulating critical time period maturation in humans. At later time-points, children exposed to SSRIs during pregnancy display increased internalizing behaviors (Oberlander et al., 2010) and decreased scores on psychomotor developmental scales (Casper et al., 2011). The most worrisome finding comes from a recent study reporting a two-fold increase in the risk for autism-spectrum disorders in children exposed to SSRIs during pregnancy (Croen et al., 2011). "
+https://www.endo-world.com/resources/e-learning-patient-education/general-guides/harmful-effects-of-medicines-on-the-adult-digestive-system

Life Hacks for Health

User Tools

Site Tools

Differences

Page Tools